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Jerold Chun with brain graphic

Alzheimer’s disease
breakthrough

Never-before-seen DNA recombination in the brain
reveals a potential near-term treatment.
 

Read the story       Watch the video

  • Cancer
  • Immunity
  • Neuroscience and Aging
  • Sanford Childrens Health Research Center
Cancer

The Institute’s Cancer Center is one of only seven NCI-designated basic cancer research centers in the nation. We couple fundamental biological research with early translational studies to find new, innovative therapies that restore hope to cancer patients and their families.

Learn more

Garth Powis D. Phil., headshot

Meet a Scientist

Garth Powis, D. Phil.

Jeanne and Gary Herberger Leadership Chair in Cancer Research

Dr. Powis studies the mechanisms that enable cancer cells to survive stress. 

All Scientists

Jamey Marth, Ph.D. standing in the lab

Meet a Scientist

Jamey Marth, Ph.D.

Professor, Tumor Microenvironment and Cancer Immunology Program

Dr. Marth’s laboratory incorporates biology, engineering, and nanotechnologies to expand biomedical research capabilities.

All Scientists

Francesca Marassi headshot

Meet a Scientist

Francesca Marassi, Ph.D.

Professor, Cancer Metabolism and Signaling Networks Program

Molecules are the building blocks of cellular life. Knowing their structures is key for understanding the basic mechanisms of…

All Scientists

Pancreas in human body

Press Release

Compound discovered at Sanford Burnham Prebys advances into Phase 1 trial for pancreatic cancer

All Press Releases

Epigenetics Symposium-Lorenzo Puri, Ani Deshpande, Peter Adams

Beaker Blog

World-renowned scientists speak at SBP’s symposium on a booming research area: epigenetics

All Blogs

Svasti Haricharan, Ph.D.

Beaker Blog

SBP scientist awarded Susan G. Komen® and NIH grants to advance breast cancer research

All Blogs

Ani Deshpande, Ph.D.

Beaker Blog

5 things to know about acute myeloid leukemia (AML)

All Blogs

Immunity

The human immune system is made up of a network of cells, tissues and organs that fight off disease. It can also turn against the body causing autoimmune disorders, such as rheumatoid arthritis, lupus, Crohn’s disease and psoriasis. Increasingly, scientists are learning how to help the body’s immune system to combat cancer. 

Learn more

Carl Ware

Meet a Scientist

Carl F. Ware, Ph.D.

Director, Infectious and Inflammatory Diseases Center

Dr. Ware’s research is directed at defining the intercellular communication pathways controlling immune responses.

All Scientists

Sumit Chanda profile photo

Meet a Scientist

Sumit Chanda, Ph.D.

Director and Professor, Immunity and Pathogenesis Program

The Chanda lab is interested in unraveling the molecular bases for these complex host-pathogen interactions, which will not only…

All Scientists

Alex Strongin, Ph.D., in the lab

Meet a Scientist

Alex Strongin, Ph.D., D.Sci.

Professor, Bioinformatics and Structural Biology Program

All Scientists

Adam Godzik

Meet a Scientist

Adam Godzik, Ph.D.

Adjunct Professor, Bioinformatics and Structural Biology Program

All Scientists

Eli Lilly Co. and SBP

Press Release

Immune therapy developed through Sanford Burnham Prebys and Lilly collaboration enters Phase 1 clinical trial

All Press Releases

Sepsis bacteria in blood

Press Release

Path to deadly sepsis varies by bacterial infection

All Press Releases

Maximiliano_DAngelo

Press Release

Nuclear pore functions are essential for T cell survival

All Press Releases

Neuroscience and Aging

Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast—to give one example, by 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million.

Learn more

Rolf Bodmer

Meet a Scientist

Rolf Bodmer, Ph.D.

Director and Professor, Development, Aging and Regeneration Program

All Scientists

evan snyder

Meet a Scientist

Evan Snyder, M.D., Ph.D.

Professor, Human Genetics Program

All Scientists

huaxi hu

Meet a Scientist

Huaxi Xu, Ph.D.

Jeanne and Gary Herberger Leadership Chair in Neuroscience Research

Dr. Xu’s research efforts focus on understanding the molecular events that underlie the pathogenesis of Alzheimer’s Disease.

All Scientists

Jerold Chun, M.D., Ph.D.

Press Release

Thousands of DNA changes in the developing brain revealed by machine learning

All Press Releases

Pier Lorenzo Puri, M.D., senior author of the study, professor in the Development, Aging and Regeneration Program at SBP

Press Release

Duchenne muscular dystrophy: How muscle cells journey to the dark side

All Press Releases

Headshot of Yingjun Zhao, research assistant professor at SBP

Beaker Blog

SBP scientist awarded BrightFocus Foundation grant to advance Alzheimer’s research

All Blogs

abstract image of two people with mosaic in background

Beaker Blog

Surprising science: Not all our cells have the same DNA

All Blogs

Sanford Childrens Health Research Center

Genetic diseases in children are rare, and often incurable. Research insights into the genes and environmental factors that play a role in the development of childhood diseases are leading to better ways to more accurately diagnose, treat and cure children with disease.

Learn more

Yu Yamaguchi headshot

Meet a Scientist

Yu Yamaguchi, M.D., Ph.D.

Professor, Human Genetics Program

Dr. Yamaguchi’s studies the role of proteoglycans and glycosaminoglycans in the context of development and human disorders.

All Scientists

Hudson Freeze, Ph.D. headshot

Meet a Scientist

Hudson Freeze, Ph.D.

Director and Professor, Human Genetics Program

Dr. Freeze’s research focuses on the pathology resulting from faulty glycosylation, the process of adding carbohydrate (sugar)…

All Scientists

Duc Dong, Ph.D., headshot

Meet a Scientist

Duc Dong, Ph.D.

Associate Dean of Admissions, SBP Graduate School

Dr. Dong’s goal is to uncover fundamental insight into basic and biomedical science through the rigorous investigation of the…

All Scientists

José Luis Millán, Ph.D. headshot

Meet a Scientist

José Luis Millán, Ph.D.

Professor, Human Genetics Program

Dr. Millán works on understanding the mechanisms that control normal skeletal mineralization and elucidating the…

All Scientists

Monica Zaring_Saul-Wilson Syndrome

Press Release

Solving a medical mystery: Cause of rare type of dwarfism discovered

All Press Releases

Hudson Freeze, Ph.D.

Press Release

Mannose’s unexpected effects on the microbiome and weight gain

All Press Releases

Rare Disease Day group photo

Beaker Blog

SBP Rare Disease Day Symposium: We can’t do it alone

All Blogs

Rare disease

Beaker Blog

Diagnosing a rare disease in children

All Blogs

Cancer

Cancer

The Institute’s Cancer Center is one of only seven NCI-designated basic cancer research centers in the nation. We couple fundamental biological research with early translational studies to find new, innovative therapies that restore hope to cancer patients and their families.

Learn more

Garth Powis D. Phil., headshot

Meet a Scientist

Garth Powis, D. Phil.

Jeanne and Gary Herberger Leadership Chair in Cancer Research

Dr. Powis studies the mechanisms that enable cancer cells to survive stress. 

All Scientists

Jamey Marth, Ph.D. standing in the lab

Meet a Scientist

Jamey Marth, Ph.D.

Professor, Tumor Microenvironment and Cancer Immunology Program

Dr. Marth’s laboratory incorporates biology, engineering, and nanotechnologies to expand biomedical research capabilities.

All Scientists

Francesca Marassi headshot

Meet a Scientist

Francesca Marassi, Ph.D.

Professor, Cancer Metabolism and Signaling Networks Program

Molecules are the building blocks of cellular life. Knowing their structures is key for understanding the basic mechanisms of…

All Scientists

Pancreas in human body

Press Release

Compound discovered at Sanford Burnham Prebys advances into Phase 1 trial for pancreatic cancer

All Press Releases

Epigenetics Symposium-Lorenzo Puri, Ani Deshpande, Peter Adams

Beaker Blog

World-renowned scientists speak at SBP’s symposium on a booming research area: epigenetics

All Blogs

Svasti Haricharan, Ph.D.

Beaker Blog

SBP scientist awarded Susan G. Komen® and NIH grants to advance breast cancer research

All Blogs

Ani Deshpande, Ph.D.

Beaker Blog

5 things to know about acute myeloid leukemia (AML)

All Blogs

Immunity

Immunity

The human immune system is made up of a network of cells, tissues and organs that fight off disease. It can also turn against the body causing autoimmune disorders, such as rheumatoid arthritis, lupus, Crohn’s disease and psoriasis. Increasingly, scientists are learning how to help the body’s immune system to combat cancer. 

Learn more

Carl Ware

Meet a Scientist

Carl F. Ware, Ph.D.

Director, Infectious and Inflammatory Diseases Center

Dr. Ware’s research is directed at defining the intercellular communication pathways controlling immune responses.

All Scientists

Adam Godzik

Meet a Scientist

Adam Godzik, Ph.D.

Adjunct Professor, Bioinformatics and Structural Biology Program

All Scientists

Sumit Chanda profile photo

Meet a Scientist

Sumit Chanda, Ph.D.

Director and Professor, Immunity and Pathogenesis Program

The Chanda lab is interested in unraveling the molecular bases for these complex host-pathogen interactions, which will not only…

All Scientists

Alex Strongin, Ph.D., in the lab

Meet a Scientist

Alex Strongin, Ph.D., D.Sci.

Professor, Bioinformatics and Structural Biology Program

All Scientists

Eli Lilly Co. and SBP

Press Release

Immune therapy developed through Sanford Burnham Prebys and Lilly collaboration enters Phase 1 clinical trial

All Press Releases

Sepsis bacteria in blood

Press Release

Path to deadly sepsis varies by bacterial infection

All Press Releases

Maximiliano_DAngelo

Press Release

Nuclear pore functions are essential for T cell survival

All Press Releases

Neuroscience and Aging

Neuroscience and Aging

Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast—to give one example, by 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million.

Learn more

evan snyder

Meet a Scientist

Evan Snyder, M.D., Ph.D.

Professor, Human Genetics Program

All Scientists

huaxi hu

Meet a Scientist

Huaxi Xu, Ph.D.

Jeanne and Gary Herberger Leadership Chair in Neuroscience Research

Dr. Xu’s research efforts focus on understanding the molecular events that underlie the pathogenesis of Alzheimer’s Disease.

All Scientists

Rolf Bodmer

Meet a Scientist

Rolf Bodmer, Ph.D.

Director and Professor, Development, Aging and Regeneration Program

All Scientists

Jerold Chun, M.D., Ph.D.

Press Release

Thousands of DNA changes in the developing brain revealed by machine learning

All Press Releases

Pier Lorenzo Puri, M.D., senior author of the study, professor in the Development, Aging and Regeneration Program at SBP

Press Release

Duchenne muscular dystrophy: How muscle cells journey to the dark side

All Press Releases

Headshot of Yingjun Zhao, research assistant professor at SBP

Beaker Blog

SBP scientist awarded BrightFocus Foundation grant to advance Alzheimer’s research

All Blogs

abstract image of two people with mosaic in background

Beaker Blog

Surprising science: Not all our cells have the same DNA

All Blogs

Sanford Childrens Health Research Center

Sanford Childrens Health Research Center

Genetic diseases in children are rare, and often incurable. Research insights into the genes and environmental factors that play a role in the development of childhood diseases are leading to better ways to more accurately diagnose, treat and cure children with disease.

Learn more

Yu Yamaguchi headshot

Meet a Scientist

Yu Yamaguchi, M.D., Ph.D.

Professor, Human Genetics Program

Dr. Yamaguchi’s studies the role of proteoglycans and glycosaminoglycans in the context of development and human disorders.

All Scientists

José Luis Millán, Ph.D. headshot

Meet a Scientist

José Luis Millán, Ph.D.

Professor, Human Genetics Program

Dr. Millán works on understanding the mechanisms that control normal skeletal mineralization and elucidating the…

All Scientists

Duc Dong, Ph.D., headshot

Meet a Scientist

Duc Dong, Ph.D.

Associate Dean of Admissions, SBP Graduate School

Dr. Dong’s goal is to uncover fundamental insight into basic and biomedical science through the rigorous investigation of the…

All Scientists

Hudson Freeze, Ph.D. headshot

Meet a Scientist

Hudson Freeze, Ph.D.

Director and Professor, Human Genetics Program

Dr. Freeze’s research focuses on the pathology resulting from faulty glycosylation, the process of adding carbohydrate (sugar)…

All Scientists

Monica Zaring_Saul-Wilson Syndrome

Press Release

Solving a medical mystery: Cause of rare type of dwarfism discovered

All Press Releases

Hudson Freeze, Ph.D.

Press Release

Mannose’s unexpected effects on the microbiome and weight gain

All Press Releases

Rare Disease Day group photo

Beaker Blog

SBP Rare Disease Day Symposium: We can’t do it alone

All Blogs

Rare disease

Beaker Blog

Diagnosing a rare disease in children

All Blogs

Drug Discovery and Technology

SBP has the talent and resources to accelerate the development of new therapeutics.

Pebys Center robot arm

Prebys Center

Through development and application of modern drug discovery technologies, SBP is uniquely positioned to make next-generation medicines.

Learn more

slide in microscope

Shared Resources

Our cores provide advanced technology, expertise and instrumentation to investigators.

Learn more

scientist and assay plate

Other Platforms

SBP innovates and maintains key technologies and partnerships to facilitate research.

Center for Stem Cells and Regenerative Medicine
SBP-GSK Center for Translational Neuroscience

Pebys Center robot arm

Prebys Center

Through development and application of modern drug discovery technologies, SBP is uniquely positioned to make next-generation medicines.

Learn more

slide in microscope

Shared Resources

Our cores provide advanced technology, expertise and instrumentation to investigators.

Learn more

Pebys Center robot arm

Other Platforms

SBP innovates and maintains key technologies and partnerships to facilitate research.

Center for Stem Cells and Regenerative Medicine
SBP-GSK Center for Translational Neuroscience

SBP Pipeline – Current Projects

SBP Pipeline graphic

Learn more

Drug discovery projects

News

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All News

Scientist analyzing DNA gel- Sanford Burnham Prebys

Press Release

December 11, 2018

Loss of two genes drives a deadly form of colorectal cancer, reveals a potential treatment

Colorectal cancers arise from earlier growths, called polyps, found on the inner surface of the colon. Scientists are now learning that polyps use two distinct…

Read more

Hudson Freeze, Ph.D., Sanford Burnham Prebys

Beaker Blog December 11, 2018
Parents gain answers about their child’s mysterious condition, thanks to SBP scientists

For the parents of a six-year-old Hispanic boy and a seven-year-old Qatari girl, answers remained elusive. Both children had alarming symptoms, including…

Read more

immunity logo

Paper of the Week
Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance

Read more

Epigenetics Symposium-Lorenzo Puri, Ani Deshpande, Peter Adams

Beaker Blog November 28, 2018
World-renowned scientists speak at SBP’s symposium on a booming research area: epigenetics

DNA contains more information than scientists previously thought. A booming field of research called epigenetics is uncovering DNA alterations that affect…

Read more

Gaurav Pathria, Garth Powis- Eric Dudle Scholarship

Beaker Blog November 28, 2018
Scholarship honoring late SBP scientist Eric Dudl awarded at Cancer Center Open House

Twelve years ago, Eric Dudl had begun his postdoctoral research at Sanford Burnham Prebys Biomedical Research Institute (SBP) when he received shocking news. He…

Read more

Team Sanford Burnham Prebys-Padres Pedal the Cause

Beaker Blog November 27, 2018
Team SBP raises more than $30,000—and counting—for cancer research at Padres Pedal the Cause

More than 60 scientists, staff and supporters of Sanford Burnham Prebys Medical Discovery Institute (SBP) ran, walked, biked and volunteered to raise critical…

Read more

Brain with and without Alzheimers Disease

In the News

November 21, 2018

‘Landmark study’ shows brain cells revamp their DNA, perhaps sparking Alzheimer’s disease

Science Magazine

Read more

Beta amyloid protein-Alzheimers disease

In the News

November 21, 2018

Morphing brain DNA hints at a whole new way to treat Alzheimer’s

New Scientist

Read more

San Diego Union-Tribune Logo

In the News

November 21, 2018

HIV drugs may help people with Alzheimers and Down syndrome, says new hypothesis on Alzheimers origins

The San Diego Union-Tribune

Read more

3D illustration of Interconnected neurons with electrical pulses

Press Release

November 21, 2018

Never-before-seen DNA recombination in the brain linked to Alzheimer’s disease

New technology reveals DNA in neurons is “mixed and matched,”producing thousands of previously unknown gene variations—and identifying a potential near-term treatment for Alzheimer’s disease

Read more

Nature logo

Paper of the Week
Somatic APP gene recombination in Alzheimer’s disease and normal neurons

Read more

Sanford Burnham Prebys 2018 Gala

In the News

November 16, 2018

Making Medical Miracles: SBP’s fundraising gala

The San Diego Union-Tribune

Read more

SBP Insights graphic

Events
Feb, 2019
7th

SBP Insights: Heart Disease

All Events

Dec, 2018
4th

Dr. Costas Koumenis and Dr. Michael Karin

12:00 PM

2:00 PM

Time Zone:
PT

Fishman Auditorium

Dec, 2018
7th

3rd Annual SBP/Mayo/UCSD/Charité Symposium

8:30 AM

5:00 PM

Time Zone:
PT

Fishman Auditorium

Dec, 2018
10th

Selective autophagy in aging and age related disorders

12:00 PM

1:00 PM

Time Zone:
PT

Fishman Auditorium

Feb, 2019
28th

10th Annual SBP Rare Disease Day Symposium

9:00 AM

5:00 PM

Time Zone:
PT

Building 12, SBP Auditorium

5.7m

5.7 million Americans are living with Alzheimer’s. By 2050, this number is projected to rise to nearly 14 million. SBP research hopes to change that.

Learn more

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